Beskrivelse
Metamizole – Analgesic and Antipyretic Medicine (Rx, country-dependent)
Metamizole is a non-opioid analgesic and antipyretic medicine that is authorised in a number of EU countries for moderate to severe pain and fever that cannot be controlled with other treatments. It is also known as dipyrone in some markets.
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Metamizole is used when a stronger pain-relieving or fever-reducing option is needed and other treatments have not been effective. Regulatory reviews note that its authorised uses vary by country, and some products are also used for pain after surgery, injury-related pain, cancer-related pain, and fever.
Its use is more restricted than many common pain relievers because of a rare but serious risk of agranulocytosis and other severe blood-related reactions. The EMA has issued measures to reduce serious outcomes from this known side effect, and the FDA previously withdrew human dipyrone products in the U.S. after reports of agranulocytosis.
Key Details
- Active ingredient: metamizole sodium / dipyrone.
- Drug class: non-opioid analgesic and antipyretic.
- Main uses: moderate to severe pain and fever not controlled with other treatments.
- Prescription status: prescription-only in many markets; availability varies by country.
- U.S. status: not approved for human use; FDA withdrew human dipyrone products in 1977 due agranulocytosis reports.
Specifikationer
- Formulations: tablets, oral drops, and injectable forms may exist depending on country and brand.
- Therapeutic category: analgesic / antipyretic.
- Clinical role: short-term treatment when other pain or fever medicines are not suitable or effective.
- Major safety concern: risk of agranulocytosis and other serious blood disorders.
- Pregnancy and breastfeeding: EMA recommended harmonising contraindications and precautions during pregnancy and breastfeeding across EU products.
Safety and Precautions
Metamizole should not be used by people who have previously had agranulocytosis caused by metamizole or similar pyrazolone medicines, or by people with bone marrow problems or conditions affecting blood cell production or function.
