Descripción
Ciprofloxacin – Fluoroquinolone Antibiotic (Rx)
Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat a wide range of bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, leading to bacterial cell death.
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It is commonly prescribed for infections such as urinary tract infections (UTIs), respiratory tract infections, gastrointestinal infections, skin infections, and certain sexually transmitted infections. Ciprofloxacin is particularly effective against many Gram-negative bacteria.
Key Details
- Active Ingredient: Ciprofloxacin
- Drug Class: Fluoroquinolone antibiotic
- Indications:
- Urinary tract infections (UTIs)
- Respiratory tract infections
- Gastrointestinal infections (e.g., traveler’s diarrhea)
- Skin and soft tissue infections
- Bone and joint infections
- Mechanism of Action: Inhibits DNA gyrase & topoisomerase IV → bactericidal effect
- Spectrum: Broad-spectrum (strong Gram-negative coverage)
- Prescription Status: Prescription-only medicine
Especificaciones
- Dosage Forms:
- Oral tablets
- Oral suspension
- Intravenous (IV) infusion
- Ophthalmic and otic solutions
- Common Strengths (oral): 250 mg, 500 mg, 750 mg
- Administration: Oral or IV depending on severity
- Dosing Frequency: Usually twice daily (varies by infection)
- Onset of Action: Within hours of administration
- Half-Life: ~4 hours
- Metabolism: Partial hepatic metabolism
- Excretion: Primarily renal
- Storage: Room temperature
Dosage & Administration
- Dose depends on type and severity of infection
- Typical adult oral dosing: 250–750 mg every 12 hours
- Complete the full prescribed course to prevent resistance
- Take with water; avoid taking simultaneously with antacids or calcium-rich products (they reduce absorption)
Compatibility / Suitable Use
- Adults with confirmed or suspected bacterial infections
- Patients requiring broad-spectrum antibiotic therapy
- Suitable for oral or IV treatment depending on severity
- Must be used under medical supervision
Contraindicaciones
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Use with tizanidine (contraindicated interaction)
Why Choose Ciprofloxacin?
Ciprofloxacin is a widely used broad-spectrum antibiotic with strong activity against Gram-negative bacteria. Its availability in multiple forms (oral and IV) and effectiveness in treating diverse infections make it a versatile option in clinical practice.