Citodon – Combination Analgesic (Paracetamol + Codeine) for Moderate Pain (Rx)

Citodon is a combination analgesic containing paracetamol (acetaminophen) and codeine phosphate, used for the treatment of moderate pain that is not adequately controlled by non-opioid analgesics alone.

Paracetamol provides analgesic and antipyretic effects by acting centrally to reduce pain and fever.
Codeine is a weak opioid analgesic that is metabolized into morphine in the body, contributing to pain relief through opioid receptor activation in the central nervous system.

This combination offers synergistic pain relief, but requires medical supervision due to the opioid component.

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Key Details

Active Ingredients: Paracetamol + Codeine phosphate
Drug Class: Combination analgesic (non-opioid + opioid)
Indications:
- Moderate acute pain
- Post-operative pain
- Musculoskeletal pain (short-term use)
Mechanism of Action:
- Paracetamol: central analgesic/antipyretic effect
- Codeine: opioid receptor agonist (prodrug → morphine)
Prescription Status: Prescription-only medicine (controlled in many countries)

Specifications

Dosage Forms: Oral tablets
Common Strengths:
- Paracetamol 500 mg + Codeine 30 mg (varies by market)
Administration: Oral
Onset of Action: ~30–60 minutes
Duration of Action: ~4–6 hours
Metabolism: Hepatic (codeine via CYP2D6 to morphine)
Excretion: Renal
Storage: Room temperature

Dosage & Administration

Typically taken every 4–6 hours as needed for pain
Maximum daily dose must not exceed recommended paracetamol limits
Use for the shortest duration possible
Dose must be individualized by a healthcare professional

Compatibility / Suitable Use

Patients with moderate pain not relieved by paracetamol or NSAIDs alone
Short-term pain management after injury or surgery
Suitable only under medical supervision
Not intended for long-term chronic use

Contraindications

Severe respiratory depression
Acute asthma or severe breathing disorders
Severe liver disease (due to paracetamol component)
Children in many regions (especially under 12 years)
Known hypersensitivity to paracetamol or opioids

Why Choose Citodon?

Citodon provides enhanced pain relief through a combination of paracetamol and codeine, making it useful when standard painkillers are insufficient. However, it must be used carefully due to the opioid component and potential for dependence.

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