Kuvaus
Loratadiini
Loratadine is a second-generation antihistamine used to relieve symptoms caused by allergic conditions. It works by blocking histamine H1 receptors, reducing allergic responses such as sneezing, runny nose, itching, and watery eyes.
It is commonly used for allergic rhinitis (hay fever) and chronic urticaria (hives). Unlike older antihistamines, loratadine is non-sedating or minimally sedating, making it suitable for daytime use.
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Key Details
- Active Ingredient: Loratadine
- Drug Class: Second-generation antihistamine
- Indication: Allergic rhinitis, urticaria (hives), seasonal allergies
- Mechanism of Action: Selective H1 receptor antagonist → reduces histamine effects
- Route of Administration: Oral
- Prescription Status: Over-the-counter or prescription (varies by country)
Määrittelyt
- Dosage Form: Tablets, oral syrup, orally disintegrating tablets
- Available Strengths: 10 mg tablets, 1 mg/mL syrup
- Usual Dose: 10 mg
- Frequency: Once daily
- Onset of Action: 1–3 hours
- Half-Life: ~8 hours (active metabolite longer effect)
- Metabolism: Hepatic (CYP450 → desloratadine active metabolite)
- Excretion: Urine and feces
- Storage: Room temperature, dry place
Dosage & Administration
Loratadine is taken once daily, with or without food. It is used for short-term relief during allergy exposure or long-term control of chronic allergic conditions. Consistent daily use may be recommended during allergy seasons.
Safety & Precautions
- Generally well tolerated with low sedation risk
- Possible side effects: headache, dry mouth, fatigue
- Use caution in severe liver impairment (dose adjustment may be needed)
- Overdose may increase drowsiness or heart rhythm changes (rare)
- Avoid combining with alcohol in sensitive individuals
Compatibility / Suitable Use
- Suitable for adults and children (age-dependent dosing)
- Ideal for seasonal allergies and chronic urticaria
- Safe for daytime use due to minimal sedative effects
- Not intended for acute anaphylaxis treatment