Description

Dexedrine (Dextroamphetamine Sulfate) – CNS Stimulant for ADHD & Narcolepsy (Rx)

Dexedrine (dextroamphetamine sulfate) is a central nervous system (CNS) stimulant indicated for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It increases synaptic levels of dopamine and norepinephrine by promoting their release and inhibiting reuptake, leading to improved attention, focus, and wakefulness.

Dexedrine is available in both immediate-release (IR) and extended-release (Spansule®) formulations, allowing flexible dosing for symptom control throughout the day.

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Détails clés

• Active Ingredient: Dextroamphetamine sulfate
• Drug Class: CNS stimulant (amphetamine derivative)
• Indications :
  • ADHD (children ≥3 years, adolescents, adults)
  • Narcolepsie
• Mécanisme d'action : Augmente l'activité de la dopamine et de la noradrénaline dans le SNC
• Therapeutic Effects: Improved attention, reduced impulsivity, increased alertness
• Prescription Status: Controlled prescription medicine

Cahier des charges

• Formes posologiques :
  • Immediate-release tablets
  • Extended-release capsules (Spansule®)
• Available Strengths:
  • IR: 5 mg, 10 mg
  • ER: 5 mg, 10 mg, 15 mg
• Administration : Orale
• Début d'action :
  • IR: ~30–60 minutes
  • ER: ~1–2 hours
• Durée d'action :
  • IR: ~4–6 hours
  • ER: ~8–12 hours
• Half-Life: ~10–12 hours (variable)
• Metabolism: Hepatic (partial)
• Excretion: Renal (pH-dependent)
• Conservation : température ambiante

Dosage et administration

• Initial dosing: Low starting dose with gradual titration
• IR formulations: Typically taken 1–3 times daily
• ER formulations: Usually once daily in the morning
• Avoid late-day dosing to reduce insomnia risk
• Dose individualized based on clinical response

Compatibilité / Utilisation appropriée

• Patients diagnosed with ADHD requiring stimulant therapy
• Les personnes atteintes de narcolepsie
• Suitable for short-acting or extended symptom control
• Requires close medical supervision and monitoring

Contre-indications

• Maladie cardiovasculaire avancée
• Hyperthyroïdie
• History of substance abuse
• Concurrent use of monoamine oxidase inhibitors (MAOIs)
• Hypersensitivity to amphetamines

Interactions médicamenteuses

• MAOIs: Contraindicated (risk of hypertensive crisis)
• Antihypertensives: Reduced effectiveness
• Acidifying/alkalinizing agents: Alter drug excretion
• Other stimulants: Increased adverse effect risk

Why Choose Dexedrine?

Dexedrine is a well-established stimulant medication offering both immediate and extended-release options for tailored ADHD and narcolepsy management. Its efficacy in improving focus and wakefulness makes it a key option in specialist-directed treatment plans.