Description
Wegovy (Semaglutide) Weight Loss Injection
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How Wegovy Works
Wegovy mimics glucagon-like peptide-1 (GLP-1), a hormone that regulates appetite and food intake. It acts on the brain to reduce hunger, increase satiety, slow gastric emptying, and help control cravings, which supports sustained weight loss when combined with a reduced-calorie diet and increased physical activity.
Forms and Dosage
Injection: Once-weekly subcutaneous injection, starting at 0.25 mg and gradually increasing to a maintenance dose of 2.4 mg. A higher-dose version, Wegovy HD 7.2 mg, is available for additional weight loss support.
Oral pill: A daily tablet taken with water on an empty stomach uses protective technology (SNAC) to ensure absorption. Dose strengths range up to 25 mg daily.
Effectiveness
Average weight loss: Clinical trials show adults taking Wegovy injections lost 14–15% of body weight over 68 weeks, roughly 34 pounds for someone starting at 240 pounds.
Higher-dose HD: The 7.2 mg dose led to 18.7% average weight loss, with about one-third of participants losing 25% or more of their starting weight.
Oral pill: The results were about the same, with an average weight loss of 13–14% over 64–72 weeks.
Weight loss is gradual, with the most significant changes typically occurring after 12–15 months on the maintenance dose.
Side Effects
Common side effects include nausea, vomiting, diarrhea, constipation, abdominal pain, headache, and fatigue. Most are mild and improve over time. Serious but rare side effects include the following:
- Pancreatitis
- Gallbladder disease
- Thyroid tumors (boxed warning)
- Eye complications in type 2 diabetes
- Increased heart rate
- Severe gastrointestinal issues
Safety Considerations
Not recommended for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2.
- Monitor for low blood sugar if used with insulin or sulfonylureas.
Please promptly inform a healthcare provider if you experience any vision changes, severe stomach pain, or signs of pancreatitis.
Maximizing Weight Loss
Follow a nutrient-dense, low-calorie diet with adequate protein at each meal.
- Engage in regular physical activity, including aerobic and strength training exercises.
- Prioritize sleep and stress management to support appetite regulation.
- Tailor the dose with your healthcare provider to balance effectiveness and tolerability.
Commit to long-term lifestyle changes to maintain weight loss and prevent regain.