Descrição

 Phentermine – Appetite Suppressant for Short-Term Weight Management (Rx, Controlled in Many Regions)

Phentermine is a sympathomimetic amine anorectic agent used as a short-term adjunct in weight management for patients with obesity or overweight conditions.

It works primarily by stimulating the central nervous system to increase the release of norepinephrine (and to a lesser extent dopamine) in the hypothalamus, which helps reduce appetite and increase satiety.

Phentermine is typically prescribed alongside a reduced-calorie diet, exercise, and behavioral changes, and is intended for short-term use only due to tolerance and dependence potential.

 Key Details

• Active Ingredient: Phentermine hydrochloride
• Drug Class: Sympathomimetic appetite suppressant
• Indication: Short-term management of obesity
• Mechanism of Action: CNS stimulation → appetite suppression via norepinephrine release
• Prescription Status: Controlled prescription medicine in many countries

 Specifications

• Dosage Forms: Oral capsules, tablets
• Common Strengths: 15 mg, 30 mg, 37.5 mg
• Administration: Oral (usually once daily)
• Onset of Action: Within hours
• Duration of Action: ~10–14 hours (varies by formulation)
• Half-Life: ~20 hours (approximate)
• Metabolism: Hepatic
• Excretion: Renal (unchanged and metabolites)
• Storage: Room temperature

 Dosage & Administration

• Typically taken once daily in the morning to avoid insomnia
• Must be used with dietary calorie restriction and lifestyle changes
• Treatment duration is usually a few weeks (short-term use only)
• Dose is individualized by a healthcare professional

Compatibility / Suitable Use

• Adults with BMI ≥30 (obesity) or BMI ≥27 with weight-related conditions
• Patients requiring short-term appetite control support
• Used alongside structured weight loss programs
• Not a standalone long-term weight loss solution

 Warnings & Precautions

• Risk of dependence and abuse (amphetamine-like stimulant effects)
• May increase heart rate and blood pressure
• Can cause insomnia, anxiety, and restlessness
• Avoid in patients with cardiovascular disease
• Not recommended for long-term continuous use
• Avoid late-day dosing due to stimulant effects

 Contraindications

• Severe cardiovascular disease or uncontrolled hypertension
• Hyperthyroidism
• Glaucoma
• History of drug abuse
• Use with MAO inhibitors (dangerous interaction)

Why Phentermine Is Used

Phentermine is prescribed as a short-term weight loss aid to help reduce appetite and support calorie restriction in patients struggling with obesity. It is most effective when combined with dietary changes, exercise, and behavioral support programs.