Beskrivning

Amfexa (Dexamfetamine Sulfate) – CNS Stimulant for ADHD & Narcolepsy (Rx)

Amfexa (dexamfetamine sulfate) is a central nervous system (CNS) stimulant indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in children (≥6 years), adolescents, and adults, as well as narcolepsy. It enhances cognitive function by increasing the synaptic availability of dopamine and norepinephrine in the brain.

Dexamfetamine works by promoting the release and inhibiting the reuptake of monoamines, leading to improved attention span, reduced impulsivity, and enhanced executive function. It is typically used when response to first-line treatments is inadequate or when clinically appropriate.

Nyckelfakta

• Active Ingredient: Dexamfetamine sulfate
• Drug Class: CNS stimulant (amphetamine derivative)
• Indikationer:
  • Attention deficit hyperactivity disorder (ADHD)
  • Narkolepsi
• Mechanism of Action: Increases dopamine and norepinephrine activity in the CNS
• Therapeutic Effects: Improved attention, reduced hyperactivity, increased wakefulness
• Receptstatus: Receptbelagt läkemedel som klassificeras som narkotika

Specifikationer

• Dosformations: Tabletter för oral administrering
• Available Strengths: 5 mg, 10 mg, 20 mg
• Administration: Oral, typically divided doses throughout the day
• Onset of Action: ~30–60 minutes
• Peak Effect: ~1–3 hours
• Duration of Action: ~4–6 hours
• Half-Life: ~10–12 hours (varies with urinary pH)
• Metabolism: Hepatic (partial)
• Excretion: Primarily renal (pH-dependent)
• Förvaring: Rumstemperatur

Dosering och administrering

• Initial dose (ADHD): Low dose with gradual titration
• Administer 1–3 times daily depending on clinical need
• Last dose should be taken earlier in the day to avoid insomnia
• Dose individualized based on response and tolerability

Kompatibilitet / Lämplig användning

• Patients diagnosed with ADHD requiring stimulant therapy
• Individuals with narcolepsy for wakefulness promotion
• Suitable for short-acting symptom control
• Requires strict medical supervision and monitoring

Kontraindikationer

• Hypersensitivity to dexamfetamine
• Advanced cardiovascular disease
• Hyperthyroidism
• History of drug abuse
• Concomitant use with monoamine oxidase inhibitors (MAOIs)

Varningar och försiktighetsåtgärder

• Risk of abuse, dependence, and misuse
• Kan öka hjärtfrekvens och blodtryck
• Monitor for psychiatric symptoms (e.g., anxiety, aggression)
• Growth suppression in children with long-term use
• Use caution in patients with cardiac conditions

Adverse Effects

• Common: Insomnia, decreased appetite, dry mouth, irritability
• Cardiovascular: Increased heart rate, hypertension
• CNS: Anxiety, restlessness, headache
• Long-term: Dependence, tolerance

Läkemedelsinteraktioner

• MAOIs: Contraindicated (risk of hypertensive crisis)
• Antihypertensives: Reduced efficacy
• Acidifying/alkalinizing agents: Affect excretion and levels
• Other stimulants: Increased risk of adverse effects

Why Choose Amfexa?

Amfexa provides flexible, short-acting stimulant therapy for ADHD and narcolepsy, allowing tailored dosing throughout the day. Its rapid onset and effectiveness in improving focus and alertness make it a valuable option in specialist-managed treatment plans.