Beskrivning
Viagra – PDE5 Inhibitor for Erectile Dysfunction (Rx)
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Viagra (sildenafil citrate) is a phosphodiesterase type 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) in adult men. It enhances the effect of nitric oxide (NO) by inhibiting PDE5 in the corpus cavernosum, leading to increased levels of cyclic guanosine monophosphate (cGMP), smooth muscle relaxation, and augmented penile blood flow in response to sexual stimulation.
Sildenafil requires sexual stimulation to be effective and does not initiate an erection in the absence of arousal. It is administered orally on an as-needed basis and is one of the most established first-line pharmacologic therapies for ED.
Key Details
- Active Ingredient: Sildenafil (as citrate)
- Drug Class: Phosphodiesterase type 5 (PDE5) inhibitor
- Indication: Erectile dysfunction in adult men
- Mechanism: PDE5 inhibition → ↑ cGMP → smooth muscle relaxation → increased penile blood flow
- Administration: Oral, as needed prior to sexual activity
- Prescription Status: Prescription-only medicine (availability may vary by region)
Specifikationer
- Dosage Forms: Film-coated tablets
- Available Strengths: 25 mg, 50 mg, 100 mg
- Recommended Starting Dose: 50 mg
- Dose Range: 25–100 mg based on efficacy and tolerability
- Timing: ~30–60 minutes before sexual activity (may work earlier)
- Duration of Effect: Up to ~4–5 hours
- Absorption: Delayed with high-fat meals
- Half-Life: ~3–5 hours
- Metabolism: Hepatic via CYP3A4 (major) and CYP2C9 (minor)
- Excretion: Primarily fecal (as metabolites), some renal
- Storage: Room temperature
Dosage & Administration
- Take once as needed, approximately 30–60 minutes before sexual activity
- Do not exceed one dose per day
- Adjust dose (25 mg or 100 mg) based on response and tolerability
- Consider lower starting dose in elderly or with hepatic/renal impairment
Compatibility / Suitable Use
- Adult men with erectile dysfunction
- Patients seeking on-demand oral therapy
- Use under medical supervision, especially with comorbid conditions
Kontraindikationer
- Concomitant use with nitrates (e.g., nitroglycerin)
- Concomitant use with riociguat
- Known hypersensitivity to sildenafil
- Caution/avoid in severe cardiovascular conditions where sexual activity is inadvisable
Warnings & Precautions
- Risk of hypotension, especially with vasodilators
- Potential for visual disturbances (PDE6 interaction)
- Rare cases of non-arteritic anterior ischemic optic neuropathy (NAION)
- Risk of priapism (seek urgent care if erection >4 hours)
- Use caution with alpha-blockers (dose separation/adjustment may be required)
Adverse Effects
- Common: Headache, flushing, dyspepsia, nasal congestion, dizziness
- Visual: Blue-tinged vision, blurred vision (transient)
- Cardiovascular: Hypotension, palpitations (rare)
Läkemedelsinteraktioner
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): ↑ sildenafil levels
- CYP3A4 inducers (e.g., rifampicin): ↓ efficacy
- Nitrates/riociguat: Contraindicated (severe hypotension)
- Alpha-blockers: Additive BP-lowering effect
Why Choose Viagra?
Viagra remains a first-line, evidence-based therapy for erectile dysfunction with a well-characterized safety and efficacy profile. Its on-demand dosing, predictable onset, and extensive clinical use make it a reliable option for improving erectile response when used appropriately.