Beskrivelse

Dexedrine (Dextroamphetamine Sulfate) – CNS Stimulant for ADHD & Narcolepsy (Rx)

Dexedrine (dextroamphetamine sulfate) is a central nervous system (CNS) stimulant indicated for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It increases synaptic levels of dopamine and norepinephrine by promoting their release and inhibiting reuptake, leading to improved attention, focus, and wakefulness.

Dexedrine is available in both immediate-release (IR) and extended-release (Spansule®) formulations, allowing flexible dosing for symptom control throughout the day.

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Nøgledetaljer

• Active Ingredient: Dextroamphetamine sulfate
• Lægemiddelklasse: CNS stimulerende middel (amfetamin-derivat)
• Indikationer:
  • ADHD (children ≥3 years, adolescents, adults)
  • Narkolepsi
• Virkningsmekanisme: Øger dopamin- og noradrenalinaktivitet i CNS
• Therapeutic Effects: Improved attention, reduced impulsivity, increased alertness
• Receptstatus: Receptpligtig medicin underlagt særlig kontrol

Specifikationer

• Doseringstyper
  • Tabletter med øjeblikkelig frigørelse
  • Extended-release capsules (Spansule®)
• Available Strengths:
  • IR: 5 mg, 10 mg
  • ER: 5 mg, 10 mg, 15 mg
• Administration: Oral
• Onset of Action:
  • IR: ~30–60 minutes
  • ER: ~1–2 hours
• Varighed af handling:
  • IR: ~4–6 hours
  • ER: ~8–12 hours
• Half-Life: ~10–12 hours (variable)
• Metabolisme: Hepatisk (delvis)
• Excretion: Renal (pH-dependent)
• Opbevaring ved stuetemperatur

Dosering og administration

• Initial dosing: Low starting dose with gradual titration
• IR formulations: Typically taken 1–3 times daily
• ER formulations: Usually once daily in the morning
• Avoid late-day dosing to reduce insomnia risk
• Dose individualized based on clinical response

Kompatibilitet / Egnet brug

• Patienter diagnosticeret med ADHD, der kræver stimulerende medicin
• Individuals with narcolepsy
• Suitable for short-acting or extended symptom control
• Requires close medical supervision and monitoring

Kontraindikationer

• Avanceret hjertesygdom
• Hyperthyroidisme
• History of substance abuse
• Concurrent use of monoamine oxidase inhibitors (MAOIs)
• Hypersensitivity to amphetamines

Lægemiddelinteraktioner

• MAO-hæmmere: Kontraindiceret (risiko for hypertensiv krise)
• Antihypertensives: Reduced effectiveness
• Acidifying/alkalinizing agents: Alter drug excretion
• Other stimulants: Increased adverse effect risk

Why Choose Dexedrine?

Dexedrine is a well-established stimulant medication offering both immediate and extended-release options for tailored ADHD and narcolepsy management. Its efficacy in improving focus and wakefulness makes it a key option in specialist-directed treatment plans.